screw up phr v 1 screw up your eyes/face to make the muscles in your face tight so that your eyes become narrow 眯缝着眼睛/绷紧脸 2 [I,T screw sth ↔ up]informal to spoil something or do something stupid 【非正式】 告吹; 搞糟，弄乱: I broke my ankle, so that really screwed up our holiday plans! 我摔断了脚踝，彻底打乱了我们度假的计划！